Physical activity as a treatment of non-alcoholic fatty liver disease: A systematic review.
Publication/Presentation Date
8-8-2015
Abstract
AIM: To review the effectiveness of exercise as a therapy for nonalcoholic fatty liver disease (NAFLD) and potential benefits in treating insulin resistance and atherosclerosis.
METHODS: Medline (EBSCOhost) and PubMed were searched for English-language randomized controlled trials and prospective cohort studies in human adults aged ≥ 18 which investigated the various effects of exercise alone, a combination of exercise and diet, or exercise and diet coupled with behavioral modification on NAFLD from 2010 to Feburary 2015.
RESULTS: Eighteen of 2298 available studies were chosen for critical review, which included 6925 patients. Nine (50%) studies were randomized controlled trials. Five (27.8%) studies utilized biopsy to examine the effects of physical activity on hepatic histology. The most commonly employed imaging modality to determine change in hepatic steatosis was hydrogen-magnetic resonance spectroscopy. Only two studies examined the effects of low impact physical activity for patients with significant mobility limitations and one compared the efficacy of aerobic and resistance exercise. No studies examined the exact duration of exercise required for hepatic and metabolic improvement in NAFLD.
CONCLUSION: While exercise improved hepatic steatosis and underlying metabolic abnormalities in NAFLD, more studies are needed to define the most beneficial form and duration of exercise treatment.
Volume
7
Issue
16
First Page
2041
Last Page
2052
ISSN
1948-5182
Published In/Presented At
Whitsett, M., & VanWagner, L. B. (2015). Physical activity as a treatment of non-alcoholic fatty liver disease: A systematic review. World journal of hepatology, 7(16), 2041–2052. https://doi.org/10.4254/wjh.v7.i16.2041
Disciplines
Medicine and Health Sciences
PubMedID
26261693
Department(s)
Department of Medicine
Document Type
Article