Clonal analysis of sacrococcygeal "teratomas".
Publication/Presentation Date
1-1-1996
Abstract
Congenital masses of the sacrococcygeal region commonly contain multiple tissues and have variously been subclassified as neoplasms or congenital hamartomas based on clinicopathological and embryological observations. We have used a polymerase chain reaction-based assay for nonrandom X chromosome inactivation to infer the clonality of three cogenital sacrococcygeal tumors previously diagnosed as teratomas. One solid immature teratoma was monoclonal, and a predominantly cystic histologically mature mass was polyclonal. A third immature teratoma was noninformative because of baseline asymmetry of polyclonal tissue X inactivation. We confirm that immature teratomas at this site appear to be monoclonal neoplasms and suggest that at least some histologically mature "teratomas" are more appropriately classified as hamartomas.
Volume
16
Issue
6
First Page
865
Last Page
875
ISSN
1077-1042
Published In/Presented At
Sinnock, K. L., Perez-Atayde, A. R., Boynton, K. A., & Mutter, G. L. (1996). Clonal analysis of sacrococcygeal "teratomas". Pediatric pathology & laboratory medicine : journal of the Society for Pediatric Pathology, affiliated with the International Paediatric Pathology Association, 16(6), 865–875. https://doi.org/10.1080/15513819609168710
Disciplines
Medicine and Health Sciences
PubMedID
9025885
Department(s)
Department of Obstetrics and Gynecology
Document Type
Article