Hormone therapy and insulin resistance in non-diabetic postmenopausal women: a systematic review and meta-analysis.
Publication/Presentation Date
6-18-2025
Abstract
OBJECTIVE: Menopause increases the risk of insulin resistance and cardiometabolic diseases. This study summarizes the effects of hormone therapy (HT) on insulin resistance in non-diabetic postmenopausal women.
METHOD: The study analyzed randomized controlled trials (1998-2024) that assessed the impact of HT on insulin resistance using homeostasis model assessment of insulin resistance (HOMA-IR) in non-diabetic postmenopausal women. Raw mean differences (RMDs) with 95% confidence intervals (CIs) were calculated using a random-effects model. Subgroup analysis compared estrogen alone (E alone) and estrogen plus progestogen (E + P) to placebo.
RESULTS: Seventeen randomized controlled trials with 5772 women (3644 on HT: E alone [
CONCLUSION: HT significantly lowers insulin resistance in healthy, non-diabetic postmenopausal women, with E alone yielding greater reductions than combination therapy.
First Page
1
Last Page
9
ISSN
1473-0804
Published In/Presented At
Li, T., Jiang, N. S., Kaskey, J., Schnatz, P. F., & Nudy, M. (2025). Hormone therapy and insulin resistance in non-diabetic postmenopausal women: a systematic review and meta-analysis. Climacteric : the journal of the International Menopause Society, 1–9. Advance online publication. https://doi.org/10.1080/13697137.2025.2509844
Disciplines
Medicine and Health Sciences
PubMedID
40531213
Department(s)
Department of Obstetrics and Gynecology
Document Type
Article