Comprehensive Amniotic Fluid Cytokine Profile Evaluation in Women with a Short Cervix: which Cytokine(s) Correlates Best with Outcome?
OBJECTIVE: The objective of this study was to determine whether an expanded amniotic fluid cytokine profile predicts spontaneous preterm birth in patients with short cervix in the midtrimester.
STUDY DESIGN: Amniocentesis was performed on singleton gestations between 16-24 weeks with a cervical length
RESULTS: Forty-four amniotic fluid samples were analyzed. After stepwise regression, only monocyte chemotactic protein-1 remained significant and was the most predictive of early delivery. With a cutoff of 1320 pg/mL, monocyte chemotactic protein-1 had a 69% sensitivity, 83% specificity, 36% positive predictive value, and 87% negative predictive value to predict spontaneous preterm birth within 1 week of amniocentesis (P = .015).
CONCLUSION: Among 25 cytokines, monocyte chemotactic protein-1 was most predictive of spontaneous preterm birth.
Published In/Presented At
Keeler, S. M., Kiefer, D. G., Rust, O. A., Vintzileos, A., Atlas, R. O., Bornstein, E., & Hanna, N. (2009). Comprehensive amniotic fluid cytokine profile evaluation in women with a short cervix: which cytokine(s) correlates best with outcome?. American Journal Of Obstetrics And Gynecology, 201(3), 276.e1-6. doi:10.1016/j.ajog.2009.05.045
Obstetrics and Gynecology
Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology Faculty