Correlation Between Umbilical Artery and Vein Levels of Interleukin-6 and Soluble Intracellular Adhesion Molecule-1

Publication/Presentation Date

3-1-1997

Abstract

This study was designed to determine whether umbilical artery levels of both interleukin-6 (IL-6) and soluble intracellular adhesion molecule-1 (sICAM-1) correlate with levels in the umbilical vein. Paired umbilical artery-vein specimens were assayed for IL-6 and sICAM-1. The paired-sign test was used to compare umbilical artery vein levels of IL-6 and sICAM-1. Spearman rank correlation was used to determine relationships between paired umbilical artery-vein levels for a variety of clinical subgroups. For 23 paired samples overall, umbilical artery levels were greater than corresponding vein levels for both IL-6 (P = .039) and sICAM-1 (P = .035). Artery-vein correlations were significant for IL-6 (rho = 0.845, P = .001) and sICAM-1 (rho = 0.806, P = .0002). Correlations were not influenced by prematurity, route of delivery, labor, or neonatal sepsis. In conclusion, umbilical artery levels of IL-6 and sICAM-1 correlate significantly with umbilical vein levels.

Volume

6

Issue

2

First Page

67

Last Page

70

ISSN

1057-0802

Disciplines

Hematology | Maternal, Child Health and Neonatal Nursing | Medical Sciences | Medical Specialties | Medicine and Health Sciences | Obstetrics and Gynecology

PubMedID

9086419

Department(s)

Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology Faculty

Document Type

Article

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