A comparative study of ketorolac (Toradol) and magnesium sulfate for arrest of preterm labor.
BACKGROUND: We evaluated the efficacy and safety of ketorolac (Toradol).
METHODS: In this prospective trial, 88 women in confirmed preterm labor at < or =32 weeks' gestation were randomized to receive magnesium sulfate given as an initial 6 g intravenous bolus followed by continuous infusion therapy (2 to 6 g/hr) or intramuscularly administered ketorolac (60 mg loading dose) followed by 30 mg every 6 hours for a maximum of 24 hours.
RESULTS: The study groups were similar with respect to age, parity, cervical status, and gestational age on admission. Ketorolac was more rapid (2.71 hr+/-2.16) in the arrest of preterm labor than was magnesium sulfate (6.22 hr+/-5.65). No patient required discontinuance of either drug due to adverse effects. There was no difference in the incidence of neonatal complications between the two groups.
CONCLUSION: In gestations with preterm labor at <32 >weeks, ketorolac appears to be an appropriate first-line tocolytic agent.
Published In/Presented At
Schorr, S. J., Ascarelli, M. H., Rust, O. A., Ross, E. L., Calfee, E. L., Perry, K. G., Jr, & Morrison, J. C. (1998). A comparative study of ketorolac (Toradol) and magnesium sulfate for arrest of preterm labor. Southern medical journal, 91(11), 1028–1032. https://doi.org/10.1097/00007611-199811000-00007
Medicine and Health Sciences
Department of Obstetrics and Gynecology