Fascin over expression is associated with dysplastic changes in sinonasal inverted papillomas: a study of 47 cases.
Publication/Presentation Date
9-1-2009
Abstract
Sinonasal inverted papilloma (IP) is a primary benign lesion with a tendency for local recurrence. Malignant transformation may develop in up to 15% of cases. Fascin (Fascin 1) is an actin cross-link binding protein required for the formation of actin-based cell-surface protrusions and cell motility. Fascin up-regulation in lung, gastric, breast and hepatobiliary carcinomas correlates with aggressiveness and decreased survival. Here we evaluate immunohistochemical expression of fascin in 47 sinonasal IPs from 34 patients. Fascin over-expression is significantly more common in sinonasal IP with high-grade dysplasia than in those with no dysplastic or low-grade dysplastic epithelium (P = 0.0001). No significant change in fascin expression is seen with recurrence. Over expression of fascin in high-grade dysplastic epithelium in IP may be associated with tumor progression and malignant transformation.
Volume
3
Issue
3
First Page
212
Last Page
216
ISSN
1936-0568
Published In/Presented At
Wu, H. H., Zafar, S., Huan, Y., Yee, H., Chiriboga, L., & Wang, B. Y. (2009). Fascin over expression is associated with dysplastic changes in sinonasal inverted papillomas: a study of 47 cases. Head and neck pathology, 3(3), 212–216. https://doi.org/10.1007/s12105-009-0133-2
Disciplines
Medicine and Health Sciences
PubMedID
20596974
Department(s)
Department of Pathology and Laboratory Medicine
Document Type
Article
Comments
Originally presented as Fascin Over-Expression is Associated with Dysplastic Changes in Sinonasal Inverted Papillomas- A Study of 32 Cases, at Annual Meeting of USCAP, 2008.