Title

Fascin over expression is associated with dysplastic changes in sinonasal inverted papillomas: a study of 47 cases.

Publication/Presentation Date

9-1-2009

Abstract

Sinonasal inverted papilloma (IP) is a primary benign lesion with a tendency for local recurrence. Malignant transformation may develop in up to 15% of cases. Fascin (Fascin 1) is an actin cross-link binding protein required for the formation of actin-based cell-surface protrusions and cell motility. Fascin up-regulation in lung, gastric, breast and hepatobiliary carcinomas correlates with aggressiveness and decreased survival. Here we evaluate immunohistochemical expression of fascin in 47 sinonasal IPs from 34 patients. Fascin over-expression is significantly more common in sinonasal IP with high-grade dysplasia than in those with no dysplastic or low-grade dysplastic epithelium (P = 0.0001). No significant change in fascin expression is seen with recurrence. Over expression of fascin in high-grade dysplastic epithelium in IP may be associated with tumor progression and malignant transformation.

Volume

3

Issue

3

First Page

212

Last Page

216

ISSN

1936-0568

Comments

Originally presented as Fascin Over-Expression is Associated with Dysplastic Changes in Sinonasal Inverted Papillomas- A Study of 32 Cases, at Annual Meeting of USCAP, 2008.

Disciplines

Medicine and Health Sciences

PubMedID

20596974

Department(s)

Department of Pathology and Laboratory Medicine

Document Type

Article

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