Podoplanin emerges as a functionally relevant oral cancer biomarker and therapeutic target.
Publication/Presentation Date
3-1-2018
Abstract
Oral cancer has become one of the most aggressive types of cancer, killing 140,000 people worldwide every year. Current treatments for oral cancer include surgery and radiation therapies. These procedures can be very effective; however, they can also drastically decrease the quality of life for survivors. New chemotherapeutic treatments are needed to more effectively combat oral cancer. The transmembrane receptor podoplanin (PDPN) has emerged as a functionally relevant oral cancer biomarker and chemotherapeutic target. PDPN expression promotes tumor cell migration leading to oral cancer invasion and metastasis. Here, we describe the role of PDPN in oral squamous cell carcinoma progression, and how it may be exploited to prevent and treat oral cancer.
Volume
78
First Page
126
Last Page
136
ISSN
1879-0593
Published In/Presented At
Retzbach, E. P., Sheehan, S. A., Nevel, E. M., Batra, A., Phi, T., Nguyen, A. T. P., Kato, Y., Baredes, S., Fatahzadeh, M., Shienbaum, A. J., & Goldberg, G. S. (2018). Podoplanin emerges as a functionally relevant oral cancer biomarker and therapeutic target. Oral oncology, 78, 126–136. https://doi.org/10.1016/j.oraloncology.2018.01.011
Disciplines
Medicine and Health Sciences
PubMedID
29496040
Department(s)
Department of Pathology and Laboratory Medicine
Document Type
Article