Acanthosis nigricans, vitamin D, and insulin resistance in obese children and adolescents.
OBJECTIVES: The aim of this study is to identify factors accounting for the variation in 25-hydroxyvitamin D levels in a pediatric obese population.
PATIENTS AND METHODS: One hundred and forty-nine obese children and adolescents (BMI ≥95th percentile) were evaluated in a pediatric endocrine office. Acanthosis nigricans (AN) skin lesions were rated on a 4-point scale.
RESULTS: The 25-hydroxyvitamin D levels were significantly different between those without AN and those with any severity of AN (p=
CONCLUSIONS: Season of evaluation was the main determinant of 25-hydroxyvitamin D levels. Severity of AN was a stronger predictor of 25-hydroxyvitamin D level variation than the measure of insulin resistance HOMA-IR.
Published In/Presented At
Slyper, A. H., Kashmer, L., Huang, W., & Re'em, Y. (2014). Acanthosis nigricans, vitamin D, and insulin resistance in obese children and adolescents. Journal Of Pediatric Endocrinology & Metabolism: JPEM, 27(11-12), 1107-1111. doi:10.1515/jpem-2013-0465.
Medicine and Health Sciences | Pediatrics
Department of Pediatrics, Department of Pediatrics Faculty, Department of Pediatrics Residents