Targeted intestinal deletion of Rho guanine nucleotide exchange factor 7, βPIX, impairs enterocyte proliferation, villus maturation, and mucosal defenses in mice.

Authors

Kunrong Cheng
Shannon M Larabee
Mazen Tolaymat MD, Lehigh Valley Health NetworkFollow
Marie Hanscom
Aaron C Shang
Alyssa Schledwitz
Shien Hu
Cinthia B Drachenberg
Min Zhan
Ahmed Chahdi
Jean-Pierre Raufman

Publication/Presentation Date

4-1-2021

Abstract

Rho guanine nucleotide exchange factors (RhoGEFs) regulate Rho GTPase activity and cytoskeletal and cell adhesion dynamics. βPix, a CDC42/RAC family RhoGEF encoded by

Volume

320

Issue

4

First Page

627

Last Page

627

ISSN

1522-1547

Published In/Presented At

Cheng, K., Larabee, S. M., Tolaymat, M., Hanscom, M., Shang, A. C., Schledwitz, A., Hu, S., Drachenberg, C. B., Zhan, M., Chahdi, A., & Raufman, J. P. (2021). Targeted intestinal deletion of Rho guanine nucleotide exchange factor 7, βPIX, impairs enterocyte proliferation, villus maturation, and mucosal defenses in mice. American journal of physiology. Gastrointestinal and liver physiology, 320(4), G627–G643. https://doi.org/10.1152/ajpgi.00415.2020

Disciplines

Medicine and Health Sciences | Pediatrics

PubMedID

33566751

Department(s)

Department of Pediatrics

Document Type

Article