Overcoming Obstacles to Targeting Muscarinic Receptor Signaling in Colorectal Cancer.

Authors

Osman Ali
Mazen Tolaymat MD, Lehigh Valley Health NetworkFollow
Shien Hu
Guofeng Xie
Jean-Pierre Raufman

Publication/Presentation Date

1-13-2021

Abstract

Despite great advances in our understanding of the pathobiology of colorectal cancer and the genetic and environmental factors that mitigate its onset and progression, a paucity of effective treatments persists. The five-year survival for advanced, stage IV disease remains substantially less than 20%. This review examines a relatively untapped reservoir of potential therapies to target muscarinic receptor expression, activation, and signaling in colorectal cancer. Most colorectal cancers overexpress M

Volume

22

Issue

2

ISSN

1422-0067

Published In/Presented At

Ali, O., Tolaymat, M., Hu, S., Xie, G., & Raufman, J. P. (2021). Overcoming Obstacles to Targeting Muscarinic Receptor Signaling in Colorectal Cancer. International journal of molecular sciences, 22(2), 716. https://doi.org/10.3390/ijms22020716

Disciplines

Medicine and Health Sciences | Pediatrics

PubMedID

33450835

Department(s)

Department of Pediatrics

Document Type

Article