Electrographic seizures during therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy.
Publication/Presentation Date
6-1-2011
Abstract
Electrographic seizures are common in neonates with hypoxic-ischemic encephalopathy, but detailed data are not available regarding seizure incidence during therapeutic hypothermia. The objective of this prospective study was to determine the incidence and timing of electrographic seizures in term neonates undergoing whole-body therapeutic hypothermia for hypoxic-ischemic encephalopathy as detected by conventional full-array electroencephalography for 72 hours of therapeutic hypothermia and 24 hours of normothermia. Clinical and electroencephalography data were collected from 26 consecutive neonates. Electroencephalograms were reviewed by 2 pediatric neurophysiologists. Electrographic seizures occurred in 17 of 26 (65%) patients. Seizures were entirely nonconvulsive in 8 of 17 (47%), status epilepticus occurred in 4 of 17 (23%), and seizure onset was in the first 48 hours in 13 of 17 (76%) patients. Electrographic seizures were common, were often nonconvulsive, and had onset over a broad range of times in the first days of life.
Volume
26
Issue
6
First Page
724
Last Page
728
ISSN
1708-8283
Published In/Presented At
Wusthoff, C. J., Dlugos, D. J., Gutierrez-Colina, A., Wang, A., Cook, N., Donnelly, M., Clancy, R., & Abend, N. S. (2011). Electrographic seizures during therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy. Journal of child neurology, 26(6), 724–728. https://doi.org/10.1177/0883073810390036
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
21447810
Department(s)
Department of Pediatrics
Document Type
Article