Electrographic status epilepticus and long-term outcome in critically ill children.
Publication/Presentation Date
2-4-2014
Abstract
OBJECTIVE: Electrographic seizures (ES) and electrographic status epilepticus (ESE) are common in children in the pediatric intensive care unit (PICU) with acute neurologic conditions. We aimed to determine whether ES or ESE was associated with worse long-term outcomes.
METHODS: Three hundred children with an acute neurologic condition and encephalopathy underwent clinically indicated EEG monitoring and were enrolled in a prospective observational study. We aimed to obtain follow-up data from 137 subjects who were neurodevelopmentally normal before PICU admission.
RESULTS: Follow-up data were collected for 60 of 137 subjects (44%) at a median of 2.7 years. Subjects with and without follow-up data were similar in clinical characteristics during the PICU admission. Among subjects with follow-up data, ES occurred in 12 subjects (20%) and ESE occurred in 14 subjects (23%). Multivariable analysis indicated that ESE was associated with an increased risk of unfavorable Glasgow Outcome Scale (Extended Pediatric Version) category (odds ratio 6.36, p = 0.01) and lower Pediatric Quality of Life Inventory scores (23 points lower, p = 0.001). Among subjects without prior epilepsy diagnoses ESE was associated with an increased risk of subsequently diagnosed epilepsy (odds ratio 13.3, p = 0.002). ES were not associated with worse outcomes.
CONCLUSIONS: Among children with acute neurologic disorders who were reported to be neurodevelopmentally normal before PICU admission, ESE but not ES was associated with an increased risk of unfavorable global outcome, lower health-related quality of life scores, and an increased risk of subsequently diagnosed epilepsy even after adjusting for neurologic disorder category, EEG background category, and age.
Volume
82
Issue
5
First Page
396
Last Page
404
ISSN
1526-632X
Published In/Presented At
Wagenman, K. L., Blake, T. P., Sanchez, S. M., Schultheis, M. T., Radcliffe, J., Berg, R. A., Dlugos, D. J., Topjian, A. A., & Abend, N. S. (2014). Electrographic status epilepticus and long-term outcome in critically ill children. Neurology, 82(5), 396–404. https://doi.org/10.1212/WNL.0000000000000082
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
24384638
Department(s)
Department of Pediatrics
Document Type
Article