Electrographic seizures after convulsive status epilepticus in children and young adults: a retrospective multicenter study.
Publication/Presentation Date
2-1-2014
Abstract
OBJECTIVE: To describe the prevalence, characteristics, and predictors of electrographic seizures after convulsive status epilepticus (CSE).
STUDY DESIGN: This was a multicenter retrospective study in which we describe clinical and electroencephalographic (EEG) features of children (1 month to 21 years) with CSE who underwent continuous EEG monitoring.
RESULTS: Ninety-eight children (53 males) with CSE (median age of 5 years) underwent subsequent continuous EEG monitoring after CSE. Electrographic seizures (with or without clinical correlate) were identified in 32 subjects (33%). Eleven subjects (34.4%) had electrographic-only seizures, 17 subjects (53.1%) had electroclinical seizures, and 4 subjects (12.5%) had an unknown clinical correlate. Of the 32 subjects with electrographic seizures, 15 subjects (46.9%) had electrographic status epilepticus. Factors associated with the occurrence of electrographic seizures after CSE were a previous diagnosis of epilepsy (P = .029) and the presence of interictal epileptiform discharges (P < .0005). The median (p25-p75) duration of stay in the pediatric intensive care unit was longer for children with electrographic seizures than for children without electrographic seizures (9.5 [3-22.5] vs 2 [2-5] days, Wilcoxon test, Z = 3.916, P = .0001). Four children (4.1%) died before leaving the hospital, and we could not identify a relationship between death and the presence or absence of electrographic seizures.
CONCLUSIONS: After CSE, one-third of children who underwent EEG monitoring experienced electrographic seizures, and among these, one-third experienced entirely electrographic-only seizures. A previous diagnosis of epilepsy and the presence of interictal epileptiform discharges were risk factors for electrographic seizures.
Volume
164
Issue
2
First Page
339
Last Page
346
ISSN
1097-6833
Published In/Presented At
Sánchez Fernández, I., Abend, N. S., Arndt, D. H., Carpenter, J. L., Chapman, K. E., Cornett, K. M., Dlugos, D. J., Gallentine, W. B., Giza, C. C., Goldstein, J. L., Hahn, C. D., Lerner, J. T., Matsumoto, J. H., McBain, K., Nash, K. B., Payne, E., Sánchez, S. M., Williams, K., & Loddenkemper, T. (2014). Electrographic seizures after convulsive status epilepticus in children and young adults: a retrospective multicenter study. The Journal of pediatrics, 164(2), 339–46.e462. https://doi.org/10.1016/j.jpeds.2013.09.032
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
24161223
Department(s)
Department of Pediatrics
Document Type
Article