Strategies to Maximize Enrollment in a Prospective Study of Comatose Children in the PICU.
Publication/Presentation Date
3-1-2016
Abstract
OBJECTIVES: To analyze barriers to recruitment encountered during a prospective study in the PICU and evaluate strategies implemented to improve recruitment.
DESIGN: Prospective observational study of continuous electroencephalogram monitoring in comatose children.
SETTING: PICUs at four North American institutions.
PATIENTS: Patients with a Glasgow Coma Scale score of less than or equal to 8 for at least an hour.
INTERVENTIONS: Four strategies to increase recruitment were sequentially implemented.
MEASUREMENTS AND MAIN RESULTS: The baseline enrollment rate was 2.1 subjects/mo, which increased following the single-site introduction of real-time patient screening using an online dashboard (4.5 subjects/mo), deferred consenting (5.2 subjects/mo), and weekend screening (6.1 subjects/mo). However, the subsequent addition of three new study sites was the greatest accelerator of enrollment (21 subjects/mo), representing a 10-fold increase from baseline (p < 0.0001).
CONCLUSIONS: Identifying barriers to recruitment and implementing creative strategies to increase recruitment can successfully increase enrollment rates in the challenging ICU environment.
Volume
17
Issue
3
First Page
246
Last Page
250
ISSN
1529-7535
Published In/Presented At
McBain, K. L., Payne, E. T., Sharma, R., Frndova, H., Abend, N. S., Sánchez, S. M., Gallentine, W. B., Cornett, K. M., Nash, K. B., Snead, O. C., Parshuram, C. S., Hutchison, J. S., & Hahn, C. D. (2016). Strategies to Maximize Enrollment in a Prospective Study of Comatose Children in the PICU. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 17(3), 246–250. https://doi.org/10.1097/PCC.0000000000000642
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
26825045
Department(s)
Department of Pediatrics
Document Type
Article