Refractory status epilepticus in children with and without prior epilepsy or status epilepticus.
Publication/Presentation Date
1-24-2017
Abstract
OBJECTIVE: To compare refractory convulsive status epilepticus (rSE) management and outcome in children with and without a prior diagnosis of epilepsy and with and without a history of status epilepticus (SE).
METHODS: This was a prospective observational descriptive study performed from June 2011 to May 2016 on pediatric patients (1 month-21 years of age) with rSE.
RESULTS: We enrolled 189 participants (53% male) with a median (25th-75th percentile) age of 4.2 (1.3-9.6) years. Eighty-nine (47%) patients had a prior diagnosis of epilepsy. Thirty-four (18%) patients had a history of SE. The time to the first benzodiazepine was similar in participants with and without a diagnosis of epilepsy (15 [5-60] vs 16.5 [5-42.75] minutes, p = 0.858). Patients with a diagnosis of epilepsy received their first non-benzodiazepine (BZD) antiepileptic drug (AED) later (93 [46-190] vs 50.5 [28-116] minutes, p = 0.002) and were less likely to receive at least one continuous infusion (35/89 [39.3%] vs 57/100 [57%], p = 0.03). Compared to patients with no history of SE, patients with a history of SE received their first BZD earlier (8 [3.5-22.3] vs 20 [5-60] minutes, p = 0.0073), although they had a similar time to first non-BZD AED (76.5 [45.3-124] vs 65 [32.5-156] minutes, p = 0.749). Differences were mostly driven by the patients with an out-of-hospital rSE onset.
CONCLUSIONS: Our study establishes that children with rSE do not receive more timely treatment if they have a prior diagnosis of epilepsy; however, a history of SE is associated with more timely administration of abortive medication.
Volume
88
Issue
4
First Page
386
Last Page
394
ISSN
1526-632X
Published In/Presented At
Sánchez Fernández, I., Jackson, M. C., Abend, N. S., Arya, R., Brenton, J. N., Carpenter, J. L., Chapman, K. E., Gaillard, W. D., Gaínza-Lein, M., Glauser, T. A., Goldstein, J. L., Goodkin, H. P., Helseth, A., Kapur, K., McDonough, T. L., Mikati, M. A., Peariso, K., Riviello, J., Jr, Tasker, R. C., Topjian, A. A., … pediatric Status Epilepticus Research Group (pSERG) (2017). Refractory status epilepticus in children with and without prior epilepsy or status epilepticus. Neurology, 88(4), 386–394. https://doi.org/10.1212/WNL.0000000000003550
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
28011930
Department(s)
Department of Pediatrics
Document Type
Article