Profile of neonatal epilepsies: Characteristics of a prospective US cohort.
Publication/Presentation Date
8-29-2017
Abstract
OBJECTIVE: Although individual neonatal epilepsy syndromes are rare, as a group they represent a sizable subgroup of neonatal seizure etiologies. We evaluated the profile of neonatal epilepsies in a prospective cohort of newborns with seizures.
METHODS: Consecutive newborns with seizures were enrolled in the Neonatal Seizure Registry (an association of 7 US children's hospitals). Treatment and diagnostic testing were at the clinicians' discretion. Neonates with seizures related to epileptic encephalopathies (without structural brain abnormalities), brain malformations, or benign familial epilepsies were included in this analysis.
RESULTS: Among 611 consecutive newborns with seizures, 79 (13%) had epilepsy (35 epileptic encephalopathy, 32 congenital brain malformations, 11 benign familial neonatal epilepsy [BFNE], 1 benign neonatal seizures). Twenty-nine (83%) with epileptic encephalopathy had genetic testing and 24/29 (83%) had a genetic etiology. Pathogenic or likely pathogenic
CONCLUSIONS: Neonatal epilepsy is often due to identifiable genetic causes. Genetic testing is now warranted for newborns with epilepsy in order to guide management and inform discussions of prognosis.
Volume
89
Issue
9
First Page
893
Last Page
899
ISSN
1526-632X
Published In/Presented At
Shellhaas, R. A., Wusthoff, C. J., Tsuchida, T. N., Glass, H. C., Chu, C. J., Massey, S. L., Soul, J. S., Wiwattanadittakun, N., Abend, N. S., Cilio, M. R., & Neonatal Seizure Registry (2017). Profile of neonatal epilepsies: Characteristics of a prospective US cohort. Neurology, 89(9), 893–899. https://doi.org/10.1212/WNL.0000000000004284
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
28733343
Department(s)
Department of Pediatrics
Document Type
Article