The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker: Study design and protocol.
Publication/Presentation Date
3-1-2019
Abstract
The Epilepsy Bioinformatics Study for Anti-epileptogenic Therapy (EpiBioS4Rx) is a longitudinal prospective observational study funded by the National Institute of Health (NIH) to discover and validate observational biomarkers of epileptogenesis after traumatic brain injury (TBI). A multidisciplinary approach has been incorporated to investigate acute electrical, neuroanatomical, and blood biomarkers after TBI that may predict the development of post-traumatic epilepsy (PTE). We plan to enroll 300 moderate-severe TBI patients with a frontal and/or temporal lobe hemorrhagic contusion. Acute evaluation with blood, imaging and electroencephalographic monitoring will be performed and then patients will be tracked for 2 years to determine the incidence of PTE. Validation of selected biomarkers that are discovered in planned animal models will be a principal feature of this work. Specific hypotheses regarding the discovery of biomarkers have been set forth in this study. An international cohort of 13 centers spanning 2 continents will be developed to facilitate this study, and for future interventional studies.
Volume
123
First Page
110
Last Page
114
ISSN
1095-953X
Published In/Presented At
Vespa, P. M., Shrestha, V., Abend, N., Agoston, D., Au, A., Bell, M. J., Bleck, T. P., Blanco, M. B., Claassen, J., Diaz-Arrastia, R., Duncan, D., Ellingson, B., Foreman, B., Gilmore, E. J., Hirsch, L., Hunn, M., Kamnaksh, A., McArthur, D., Morokoff, A., O'Brien, T., … Engel, J., Jr (2019). The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker: Study design and protocol. Neurobiology of disease, 123, 110–114. https://doi.org/10.1016/j.nbd.2018.07.025
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
30048805
Department(s)
Department of Pediatrics
Document Type
Article