The onset of pediatric refractory status epilepticus is not distributed uniformly during the day.
Publication/Presentation Date
8-1-2019
Abstract
PURPOSE: To evaluate whether the onset of pediatric refractory status epilepticus (rSE) is related to time of day.
METHOD: We analyzed the time of day for the onset of rSE in this prospective observational study performed from June 2011 to May 2019 in pediatric patients (1 month to 21 years of age). We evaluated the temporal distribution of pediatric rSE utilizing a cosinor analysis. We calculated the midline estimating statistic of rhythm (MESOR) and amplitude. MESOR is the estimated mean number of rSE episodes per hour if they were evenly distributed. Amplitude is the difference between MESOR and maximum rSE episodes/hour, or between MESOR and minimum rSE episodes/hour. We also evaluated the temporal distribution of time to treatment.
RESULTS: We analyzed 368 patients (58% males) with a median (p
CONCLUSIONS: The distribution of rSE onset is not uniform during the day. rSE onset shows a 24-h distribution with a peak in the mid-morning (11am-12 pm) and a trough at night (11 pm-12am).
Volume
70
First Page
90
Last Page
96
ISSN
1532-2688
Published In/Presented At
Sánchez Fernández, I., Gaínza-Lein, M., Abend, N. S., Amengual-Gual, M., Anderson, A., Arya, R., Brenton, J. N., Carpenter, J. L., Chapman, K. E., Clark, J., Farias-Moeller, R., Davis Gaillard, W., Glauser, T. A., Goldstein, J., Goodkin, H. P., Guerriero, R. M., Hecox, K., Jackson, M., Kapur, K., Kelley, S. A., … Pediatric Status Epilepticus Research Group (2019). The onset of pediatric refractory status epilepticus is not distributed uniformly during the day. Seizure, 70, 90–96. https://doi.org/10.1016/j.seizure.2019.06.017
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
31323566
Department(s)
Department of Pediatrics
Document Type
Article