Response to antiseizure medications in neonates with acute symptomatic seizures.
Publication/Presentation Date
3-1-2019
Abstract
In a prospective cohort of 534 neonates with acute symptomatic seizures, 66% had incomplete response to the initial loading dose of antiseizure medication (ASM). Treatment response did not differ by gestational age, sex, medication, or dose. The risk of incomplete response was highest for seizures due to intracranial hemorrhage and lowest for hypoxic-ischemic encephalopathy, although the difference was not significant after adjusting for high seizure burden and therapeutic hypothermia treatment. Future trial design may test ASMs in neonates with all acute symptomatic seizure etiologies and could target neonates with seizures refractory to an initial ASM.
Volume
60
Issue
3
First Page
20
Last Page
20
ISSN
1528-1167
Published In/Presented At
Glass, H. C., Soul, J. S., Chu, C. J., Massey, S. L., Wusthoff, C. J., Chang, T., Cilio, M. R., Bonifacio, S. L., Abend, N. S., Thomas, C., Lemmon, M., McCulloch, C. E., Shellhaas, R. A., & Neonatal Seizure Registry study group (2019). Response to antiseizure medications in neonates with acute symptomatic seizures. Epilepsia, 60(3), e20–e24. https://doi.org/10.1111/epi.14671
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
30790268
Department(s)
Department of Pediatrics
Document Type
Article