Feeding and developmental outcomes after neonatal seizures-A prospective observational study.
Publication/Presentation Date
9-1-2023
Abstract
OBJECTIVE: Among neonates with acute symptomatic seizures, we evaluated whether inability to take full feeds at time of hospital discharge from neonatal seizure admission is associated with worse neurodevelopmental outcomes, after adjusting for relevant clinical variables.
METHODS: This prospective, 9-center study of the
RESULTS: Among 276 infants, inability to achieve full oral feeds was associated with lower total WIDEA-FS scores (160.2±25.5 for full oral feeds vs. 121.8±42.9 for some/no oral feeds at 24 months, p< 0.001). At 12 months, a G-tube was required for 23 of the 49 (47%) infants who did not achieve full oral feeds, compared with 2 of the 221 (1%) who took full feeds at discharge (p< 0.001).
CONCLUSIONS: Inability to take full oral feeds upon hospital discharge is an objective clinical sign that can identify infants with acute symptomatic neonatal seizures who are at high risk for impaired development at 24 months.
Volume
1
Issue
3
First Page
209
Last Page
217
ISSN
2831-3267
Published In/Presented At
Roberts, K. H., Barks, J. D. E., Glass, H. C., Soul, J. S., Chang, T., Wusthoff, C. J., Chu, C. J., Massey, S. L., Abend, N. S., Lemmon, M. E., Thomas, C., Guillet, R., Rogers, E. E., Franck, L. S., McCaffery, H., Li, Y., McCulloch, C. E., & Shellhaas, R. A. (2023). Feeding and developmental outcomes after neonatal seizures-A prospective observational study. Annals of the Child Neurology Society, 1(3), 209–217. https://doi.org/10.1002/cns3.6
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
37842075
Department(s)
Department of Pediatrics
Document Type
Article