Cervicovaginal microbiome alters transcriptomic and epigenomic signatures across cervicovaginal epithelial barriers.
Publication/Presentation Date
5-7-2025
Abstract
BACKGROUND: The cervicovaginal microbiome plays a critical role in women's health, with microbial communities dominated by
RESULTS: In this study, we used RNA sequencing to characterize the transcriptional response of cervicovaginal epithelial cells exposed to the culture supernatants of common vaginal bacteria. Our findings revealed that
CONCLUSIONS: These results provide new insights into host-microbe interactions within the lower reproductive tract and suggests that modulating the vaginal microbiome could offer innovative therapeutic strategies to improve reproductive health.
ISSN
2693-5015
Published In/Presented At
Anton, L., Cristancho, A. G., Ferguson, B., Ravel, J., & Elovitz, M. A. (2025). Cervicovaginal microbiome alters transcriptomic and epigenomic signatures across cervicovaginal epithelial barriers. Research square, rs.3.rs-6171614. https://doi.org/10.21203/rs.3.rs-6171614/v1
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
40386438
Department(s)
Department of Pediatrics
Document Type
Article