FLAIR Vascular Hyperintensities as Imaging Biomarker in Pediatric Acute Ischemic Stroke.

Publication/Presentation Date

6-1-2025

Abstract

BACKGROUND: Fluid-attenuated inversion recovery vascular hyperintensities (FVH) are high signal intensities on magnetic resonance imaging resulting from sluggish or stagnant flow through vessels. This investigation describes the prevalence, risk factors, and outcomes associated with FVH in pediatric arterial ischemic stroke (AIS).

METHODS: Retrospective review of children aged 29 days to 18 years in a single institution stroke registry from 2006 to 2022 with AIS. Magnetic resonance imaging were assessed for large vessel occlusion (LVO), FVH score, modified Alberta Stroke Program Early CT Score, and AIS volume. The association between demographic and imaging factors with the presence of and high FVH burden was assessed using Fisher exact, Pearson χ

RESULTS: In total, 273 patients with AIS were screened, and 83 met the inclusion criteria. Patients were a median age of 11.6 years (range, 1 month-18 years) and 37% were female. FVH were present in 53% of the cohort. Median FVH score was 0 (interquartile range, 0-2) in those without LVO and 5.5 (interquartile range, 3-7) in those with LVO (

CONCLUSIONS: FVH are prevalent in children with AIS. FVH are associated with LVO, larger infarct size, and worse outcomes. Further study is needed to determine whether FVH can be used to identify patients who would benefit most from recanalization therapies.

Volume

56

Issue

6

First Page

1505

Last Page

1515

ISSN

1524-4628

Disciplines

Medicine and Health Sciences | Pediatrics

PubMedID

40151929

Department(s)

Department of Pediatrics

Document Type

Article

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