Development of a composite diffusion tensor imaging score correlating with short-term neurological status in neonatal hypoxic-ischemic encephalopathy.

Authors

Kengo Onda
Eva Catenaccio
Jill Chotiyanonta
Raul Chavez-Valdez
Avner Meoded
Bruno P Soares
Aylin Tekes
Harisa Spahic
Sarah C Miller
Sarah-Jane Parker
Charlamaine Parkinson
Dhananjay M Vaidya
Ernest M Graham
Carl E Stafstrom
Allen D Everett
Frances J Northington
Kenichi Oishi

Publication/Presentation Date

1-1-2022

Abstract

Hypoxic-ischemic encephalopathy (HIE) is the most common cause of neonatal acquired brain injury. Although conventional MRI may predict neurodevelopmental outcomes, accurate prognostication remains difficult. As diffusion tensor imaging (DTI) may provide an additional diagnostic and prognostic value over conventional MRI, we aimed to develop a composite DTI (cDTI) score to relate to short-term neurological function. Sixty prospective neonates treated with therapeutic hypothermia (TH) for HIE were evaluated with DTI, with a voxel size of 1 × 1 × 2 mm. Fractional anisotropy (FA) and mean diffusivity (MD) from 100 neuroanatomical regions (FA/MD

Volume

16

First Page

931360

Last Page

931360

ISSN

1662-4548

Published In/Presented At

Onda, K., Catenaccio, E., Chotiyanonta, J., Chavez-Valdez, R., Meoded, A., Soares, B. P., Tekes, A., Spahic, H., Miller, S. C., Parker, S. J., Parkinson, C., Vaidya, D. M., Graham, E. M., Stafstrom, C. E., Everett, A. D., Northington, F. J., & Oishi, K. (2022). Development of a composite diffusion tensor imaging score correlating with short-term neurological status in neonatal hypoxic-ischemic encephalopathy. Frontiers in neuroscience, 16, 931360. https://doi.org/10.3389/fnins.2022.931360

Disciplines

Medicine and Health Sciences | Pediatrics

PubMedID

35983227

Department(s)

Department of Pediatrics

Document Type

Article