Immature neurons in the primate amygdala: changes with early development and disrupted early environment.

Authors

Alexandra C McHale-Matthews
Danielle M DeCampo
Tanzy Love
Judy L Cameron
Julie L Fudge

Publication/Presentation Date

2-12-2023

Abstract

In human and nonhuman primates, the amygdala paralaminar nucleus (PL) contains immature neurons. To explore the PL’s potential for cellular growth during development, we compared PL cells in 1) infant and adolescent macaques (control, maternally-reared), and in 2) infant macaques that experienced separation from their mother in the first month of life. In maternally-reared animals, the adolescent PL had fewer immature neurons, more mature neurons, and larger immature soma volumes compared to infant PL. There were also fewer total neurons (immature plus mature) in adolescent versus infant PL, suggesting that some neurons move out of the PL by adolescence. Maternal separation did not change mean immature or mature neuron counts in infant PL. However, across all infant animals, immature neuron soma volume was strongly correlated with mature neuron counts.

ISSN

2692-8205

Published In/Presented At

McHale-Matthews, A. C., DeCampo, D. M., Love, T., Cameron, J. L., & Fudge, J. L. (2023). Immature neurons in the primate amygdala: changes with early development and disrupted early environment. bioRxiv : the preprint server for biology, 2023.02.10.528076. https://doi.org/10.1101/2023.02.10.528076

Disciplines

Medicine and Health Sciences | Pediatrics

PubMedID

36798176

Department(s)

Department of Pediatrics

Document Type

Article