Early life seizures and epileptic spasms in
Publication/Presentation Date
6-28-2023
Abstract
BACKGROUND AND OBJECTIVES: Individuals with disease-causing variants in
METHODS: We retrospectively reconstructed seizure and medication histories in weekly intervals for individuals with
RESULTS: We included 61 individuals with early onset seizures, 29 of whom had epileptic spasms. Individuals with neonatal seizures were likely to have continued seizures after the neonatal period (25/26). The risk of developing epileptic spasms was not increased in individuals with neonatal seizures or early infantile seizures (21/41 vs. 8/16; OR 1, 95% CI 0.3-3.9,
DISCUSSION: We provide a comprehensive assessment of early-onset seizures in
Published In/Presented At
Thalwitzer, K. M., Xian, J., deCampo, D., Parthasarathy, S., Magielski, J., Sullivan, K. R., Goss, J., Rigby, C. S., Boland, M., Prosser, B., Ruggiero, S. M., Syrbe, S., & Helbig, I. (2023). Early life seizures and epileptic spasms in STXBP1-related disorders. medRxiv : the preprint server for health sciences, 2023.06.26.23291892. https://doi.org/10.1101/2023.06.26.23291892
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
37425705
Department(s)
Department of Pediatrics
Document Type
Article