Sickle cell disease: ratio of blood flow velocity of intracranial to extracranial cerebral arteries--initial experience.
Publication/Presentation Date
5-1-2009
Abstract
PURPOSE: To establish reference values of the ratios of flow velocity in the middle cerebral artery (V(MCA)) and the terminal portion of the internal carotid artery (V(tICA)) to flow velocity in the extracranial portion of internal carotid artery (V(ICA)) in children with sickle cell disease (SCD).
MATERIALS AND METHODS: Institutional ethics committee approval and parental informed consent were obtained for this prospective HIPAA-compliant study. Sixty-eight children (38 female; mean age, 7.7 years +/- 3.3; range, 2-14 years) with HbSS genotype, without neurologic deficits and no history of stroke, were enrolled. Final study population comprised 56 (mean age 8.0 +/- 3.3 years, 26 females) children who underwent magnetic resonance (MR) angiography, which excluded intracranial arterial narrowing, transcranial color-coded duplex ultrasonography (US), and carotid US to determine V(MCA)/V(ICA) and V(tICA)/V(ICA) ratios from angle-corrected and uncorrected velocities. Tolerance interval estimates were used to calculate reference ranges and linear regression was used to quantify associations of Doppler parameters with age adjusted for hemoglobin and hematocrit.
RESULTS: Reference ranges in centimeters per second for mean angle-corrected V(MCA) on the left and right sides were 62-198 and 69-153; those for V(tICA) were 30-196 and 36-175; and those for V(ICA) were 18-116 and 15-95, respectively. Reference ranges for mean angle-corrected V(MCA)/V(ICA) ratio on the left and right sides were 1.2-4.0 and 0.4-3.4 and those for V(tICA)/V(IC)(A) ratio were 0.5-2.9 and 0.5-2.7, respectively. V(MCA), V(tICA), and V(tICA)/V(ICA) ratio were not age dependent, contrary to V(ICA) and V(MCA)/V(ICA) ratio, after controlling for hematocrit and hemoglobin.
CONCLUSION: The study provides reference limits for V(MCA), V(tICA), V(ICA), and velocity ratios obtained from children with SCD.
Volume
251
Issue
2
First Page
525
Last Page
534
ISSN
1527-1315
Published In/Presented At
Pawlak, M. A., Krejza, J., Rudzinski, W., Kwiatkowski, J. L., Ichord, R., Jawad, A. F., Tomaszewski, M., & Melhem, E. R. (2009). Sickle cell disease: ratio of blood flow velocity of intracranial to extracranial cerebral arteries--initial experience. Radiology, 251(2), 525–534. https://doi.org/10.1148/radiol.2512071180
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
19401577
Department(s)
Department of Pediatrics
Document Type
Article