Sickle cell disease and transcranial Doppler imaging: inter-hemispheric differences in blood flow Doppler parameters.
Publication/Presentation Date
1-1-2011
Abstract
BACKGROUND AND PURPOSE: to establish reference values of interhemispheric differences and ratios of blood flow Doppler parameters in the terminal internal carotid artery, middle cerebral artery, and anterior cerebral artery in children with sickle cell anemia.
METHODS: fifty-seven out of 74 recruited children (mean age, 7.8 ± 3.4 years; range limits, 3-14 years), who were free of neurological deficits and intracranial narrowing detectable by MRA and had flow velocities < 170 cm/s by conventional transcranial Doppler ultrasound, underwent transcranial color-coded duplex ultrasonography. Reference limits of flow parameters corrected and uncorrected for the angle of insonation were estimated using tolerance intervals, with P=0.90 for all possible data values from 95% of a population.
RESULTS: reference limits for left-to-right differences in cm/s in the mean angle-corrected and uncorrected flow velocities were -56 to 53 and -72 to 75 for middle cerebral artery, -49 to 57 and -81 to 91 for anterior cerebral artery, and -55 to 64 and -73 to 78 for terminal internal carotid artery, respectively. Respective reference limits for left-to-right velocity ratios were 0.31 to 1.84 and 0.38 to 1.75 for middle cerebral artery, 0.48 to 2.99 and 0.46 to 2.89 for anterior cerebral artery, and 0.61 to 2.56 and 0.56 to 2.23 for terminal internal carotid artery.
CONCLUSIONS: the study provides reference limits of interhemispheric differences and ratios of blood flow Doppler parameters that may be helpful in identification of intracranial arterial narrowing in children with sickle cell disease undergoing ultrasound screening for stroke prevention.
Volume
42
Issue
1
First Page
81
Last Page
86
ISSN
1524-4628
Published In/Presented At
Krejza, J., Chen, R., Romanowicz, G., Kwiatkowski, J. L., Ichord, R., Arkuszewski, M., Zimmerman, R., Ohene-Frempong, K., Desiderio, L., & Melhem, E. R. (2011). Sickle cell disease and transcranial Doppler imaging: inter-hemispheric differences in blood flow Doppler parameters. Stroke, 42(1), 81–86. https://doi.org/10.1161/STROKEAHA.110.591818
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
21088242
Department(s)
Department of Pediatrics
Document Type
Article