Focal Cerebral Arteriopathy of Childhood: Novel Severity Score and Natural History.
Publication/Presentation Date
11-1-2018
Abstract
Background and Purpose- Focal cerebral arteriopathy (FCA)-a common cause of arterial ischemic stroke in previously healthy children-often progresses over days to weeks, increasing the risk of recurrent stroke. We developed a novel severity scoring system designed to quantify FCA progression and correlate with clinical outcomes. Methods- The VIPS study (Vascular Effects of Infection in Pediatric Stroke) prospectively enrolled 355 children with arterial ischemic stroke (2010-2014), including 41 with centrally confirmed FCA. Two neuroradiologists independently reviewed FCA cerebrovascular imaging, assigning a graded severity score of zero (no involvement) to 4 (occlusion) to individual arterial segments. The FCA severity score (FCASS) was the unweighted sum. In an iterative process, we modeled scores derived from different combinations of arterial segments to identify the model that optimized correlation with clinical outcome, simplicity, and reliability. Results- The optimal FCASS summed scores from 5 arterial segments: supraclinoid internal carotid artery, A1, A2, M1, and M2. The median (interquartile range) baseline FCASS was 4 (2-6). Of 33 children with follow-up imaging, the maximum FCASS (at any time point) was 7 (5-9). Twenty-four (73%) had FCA progression on follow-up with their maximum FCASS at a median of 8 (5-35.5) days poststroke; their median FCASS increase was 4 (2.5-6). FCASS did not correlate with recurrent arterial ischemic stroke. Maximum (but not baseline) FCASS correlated with 1-year pediatric stroke outcome measures ( P=0.037). Conclusions- Our novel scoring system for FCA severity correlates with neurological outcomes in the VIPS cohort and provides a tool for FCA treatment trials under development.
Volume
49
Issue
11
First Page
2590
Last Page
2596
ISSN
1524-4628
Published In/Presented At
Fullerton, H. J., Stence, N., Hills, N. K., Jiang, B., Amlie-Lefond, C., Bernard, T. J., Friedman, N. R., Ichord, R., Mackay, M. T., Rafay, M. F., Chabrier, S., Steinlin, M., Elkind, M. S. V., deVeber, G. A., Wintermark, M., & VIPS Investigators (2018). Focal Cerebral Arteriopathy of Childhood: Novel Severity Score and Natural History. Stroke, 49(11), 2590–2596. https://doi.org/10.1161/STROKEAHA.118.021556
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
30355212
Department(s)
Department of Pediatrics
Document Type
Article