Variation in Treatment and Outcomes of Children With Acute Disseminated Encephalomyelitis.
Publication/Presentation Date
2-1-2020
Abstract
OBJECTIVES: To characterize variation in treatments and outcomes of pediatric patients admitted to children's hospitals with acute disseminated encephalomyelitis (ADEM).
METHODS: In this retrospective cohort study, we used data from the Pediatric Health Information System. Children >30 days old who were hospitalized from 2010 to 2015 with ADEM were included. Variables analyzed were treatments and admission to an ICU. Primary outcomes were discharge disposition and readmissions for relapses (ADEM readmissions) or for continued comorbidities (non-ADEM readmissions).
RESULTS: A total of 954 patients with ADEM had 1117 admissions. Treatments included steroids (80%), immunoglobulin (22%), and plasmapheresis (6.6%); 15% of admissions included none of these treatments. Treatments varied by center (
CONCLUSIONS: Significant variation in ADEM treatment exists across centers. Admission to an ICU for ADEM was associated with increased immunotherapy, additional health services at discharge, and readmission for diagnoses other than ADEM.
Volume
10
Issue
2
First Page
159
Last Page
165
ISSN
2154-1671
Published In/Presented At
Press, C. A., Kirschen, M., LaRovere, K., Risen, S., Guilliams, K. P., Chung, M., Griffith, J., Erklauer, J., Peariso, K., Ducharme-Crevier, L., Shah, S. S., Hall, M., & Wainwright, M. S. (2020). Variation in Treatment and Outcomes of Children With Acute Disseminated Encephalomyelitis. Hospital pediatrics, 10(2), 159–165. https://doi.org/10.1542/hpeds.2019-0129
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
31996356
Department(s)
Department of Pediatrics
Document Type
Article