Comparison of hematologic measurements between local and central laboratories: data from the BABY HUG trial.
Publication/Presentation Date
2-1-2013
Abstract
OBJECTIVES: To investigate the concordance of blood count indices measured locally and at a central laboratory.
DESIGN AND METHODS: In a multi-center clinical trial of hydroxyurea therapy in infants with sickle cell anemia (BABY HUG), the concordance between blood count indices measured locally and at a central laboratory was investigated.
RESULTS: Local laboratory measurements of neutrophil and monocyte counts were significantly higher (44% and 37%, respectively) compared to the central measurements (p< 0.0001), and mean corpuscular volume (MCV) was higher centrally.
CONCLUSION: Overnight shipping with processing delay causes spurious reductions in absolute neutrophil count (ANC) and absolute monocyte count (AMC) that may result in incorrect monitoring decisions in multicenter clinical trials.
Volume
46
Issue
3
First Page
278
Last Page
281
ISSN
1873-2933
Published In/Presented At
Kalpatthi, R., Thompson, B., Lu, M., Wang, W. C., Patel, N., Kutlar, A., Howard, T., Luchtman-Jones, L., Miller, S. T., & BABY HUG Investigators (2013). Comparison of hematologic measurements between local and central laboratories: data from the BABY HUG trial. Clinical biochemistry, 46(3), 278–281. https://doi.org/10.1016/j.clinbiochem.2012.10.032
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
23123915
Department(s)
Department of Pediatrics
Document Type
Article