Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage.
Publication/Presentation Date
2-19-2021
Abstract
Opportunities to interrogate the immune responses in the injured tissue of living patients suffering from acute sterile injuries such as stroke and heart attack are limited. We leveraged a clinical trial of minimally invasive neurosurgery for patients with intracerebral hemorrhage (ICH), a severely disabling subtype of stroke, to investigate the dynamics of inflammation at the site of brain injury over time. Longitudinal transcriptional profiling of CD14
Volume
6
Issue
56
First Page
529
Last Page
533
ISSN
2470-9468
Published In/Presented At
Askenase, M. H., Goods, B. A., Beatty, H. E., Steinschneider, A. F., Velazquez, S. E., Osherov, A., Landreneau, M. J., Carroll, S. L., Tran, T. B., Avram, V. S., Drake, R. S., Gatter, G. J., Massey, J. A., Karuppagounder, S. S., Ratan, R. R., Matouk, C. C., Sheth, K. N., Ziai, W. C., Parry-Jones, A. R., Awad, I. A., … ICHseq Investigators MISTIE III Investigators (2021). Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage. Science immunology, 6(56), eabd6279. https://doi.org/10.1126/sciimmunol.abd6279
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
33891558
Department(s)
Department of Pediatrics
Document Type
Article