Maternal deprivation alters expression of neural maturation gene tbr1 in the amygdala paralaminar nucleus in infant female macaques.
Publication/Presentation Date
3-1-2017
Abstract
Early parental loss is associated with social-emotional dysregulation and amygdala physiologic changes. Previously, we examined whole amygdala gene expression in infant monkeys exposed to early maternal deprivation. Here, we focus on an amygdala region with immature neurons at birth: the paralaminar nucleus (PL). We hypothesized that 1) the normal infant PL is enriched in a subset of neural maturation (NM) genes compared to a nearby amygdala subregion; and 2) maternal deprivation would downregulate expression of NM transcripts (mRNA). mRNAs for bcl2, doublecortin, neuroD1, and tbr1-genes expressed in post-mitotic neurons-were enriched in the normal PL. Maternal deprivation at either 1 week or 1 month of age resulted in PL-specific downregulation of tbr1-a transcription factor necessary for directing neuroblasts to a glutamatergic phenotype. tbr1 expression also correlated with typical social behaviors. We conclude that maternal deprivation influences glutamatergic neuronal development in the PL, possibly influencing circuits mediating social learning.
Volume
59
Issue
2
First Page
235
Last Page
249
ISSN
1098-2302
Published In/Presented At
de Campo, D. M., Cameron, J. L., Miano, J. M., Lewis, D. A., Mirnics, K., & Fudge, J. L. (2017). Maternal deprivation alters expression of neural maturation gene tbr1 in the amygdala paralaminar nucleus in infant female macaques. Developmental psychobiology, 59(2), 235–249. https://doi.org/10.1002/dev.21493
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
27917473
Department(s)
Department of Pediatrics
Document Type
Article