Effect of general anaesthesia on intraocular pressure in paediatric patients: a systematic review.
Publication/Presentation Date
4-1-2021
Abstract
OBJECTIVES: Assessment of the impact of general anaesthetic agents on intraocular pressure (IOP) in children via systematic review.
METHODS: Pubmed, Embase, and CENTRAL databases were systematically searched to identify randomised controlled trials, prospective, and interventional studies. The search included all studies through October 5, 2018 with no date or language restrictions. A linear mixed-effects regression analysis was performed to study the change in IOP after general anaesthesia (GA).
RESULTS: The strategy identified 518 studies that met search criteria. Six studies (531 eyes) were included for quantitative synthesis. Seven categories of mixed and non-mixed induction and maintenance agents were compared. When assessing all agents utilising a model of mean IOP as a function of time, IOP decreased after induction phase at a rate of -0.59 ± 0.19 mmHg/min (P value = 0.006).
CONCLUSIONS: This systematic review showed that most anaesthetic agents significantly decrease IOP over time after the induction phase of general anaesthesia in children. An understanding of the effects of GA on IOP is critical for those performing paediatric ophthalmic examinations under anaesthesia.
Volume
35
Issue
4
First Page
1205
Last Page
1212
ISSN
1476-5454
Published In/Presented At
Thanapaisal, S., Oatts, J., Zhao, J., Perez, C. I., Yang, Y., Porco, T. C., Singh, K., & Han, Y. (2021). Effect of general anaesthesia on intraocular pressure in paediatric patients: a systematic review. Eye (London, England), 35(4), 1205–1212. https://doi.org/10.1038/s41433-020-1093-8
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
32690926
Department(s)
Department of Pediatrics
Document Type
Article