The pain response to mydriatic eyedrops in preterm infants.
Publication/Presentation Date
6-1-2013
Abstract
OBJECTIVE: Evaluate physiological and behavioral pain responses of premature infants following instillation of mydriatic eyedrops for retinopathy of prematurity (ROP) examinations. While burning and stinging occurs in older patients, the infant pain response is not well characterized.
STUDY DESIGN: Vital sign and video monitor recorded infant responses before, during and after mydriatic (tropicamide 1%, phenylephrine 2.5%) administration upon first ROP exam. Two masked observers graded Premature Infant Pain Profile (PIPP) scores immediately before and following eyedrop administration. Scores < 7 indicate no/minimal pain, 7 to 12 slight/moderate, >12 severe.
RESULT: Twenty infants had mean premydriatic PIPP score 3.6 (s.d. 1.6), mean postmydriatic score 5.7 (s.d. 3.4), mean change 2.1 (s.d. 3.4) (P=0.01). One (5%) had premydriatic PIPP score ≥7, seven (35%) post scores ≥7 (P=0.07) with one >12.
CONCLUSION: Mydriatic drops cause a clinically significant pain response in one-third of infants. Non-pharmacological supportive measures are recommended for all infants until predictive factors are defined.
Volume
33
Issue
6
First Page
462
Last Page
465
ISSN
1476-5543
Published In/Presented At
Cohen, A. M., Cook, N., Harris, M. C., Ying, G. S., & Binenbaum, G. (2013). The pain response to mydriatic eyedrops in preterm infants. Journal of perinatology : official journal of the California Perinatal Association, 33(6), 462–465. https://doi.org/10.1038/jp.2012.149
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
23238569
Department(s)
Department of Pediatrics
Document Type
Article