Incidence, timing and risk factors of type 1 retinopathy of prematurity in a North American cohort.
Publication/Presentation Date
12-1-2021
Abstract
BACKGROUND/AIMS: Early detection and timely treatment of type 1 retinopathy of prematurity (ROP) can reduce the risk of blindness. To evaluate the incidence, timing and risk factors of type 1 ROP in a large, broad-risk cohort of premature infants.
METHODS: Secondary analysis of data from the two Postnatal Growth and Retinopathy of Prematurity studies. Main outcomes are the incidence and timing of type 1 ROP.
RESULTS: Among 11 463 infants (mean birth weight (BW), 1095 g; mean gestational age (GA), 28 weeks), 677 (5.9%, 95% CI 5.5% to 6.3%) developed type 1 ROP. Rate of type 1 ROP decreased with larger GA (28.8% for GA ≤23 weeks, 0.2% for GA of 31-32 weeks) and no infants with GA >32 weeks developed type 1 ROP. Type 1 ROP was first diagnosed at a median postmenstrual age (PMA) of 36 weeks (range 30-46 weeks) or postnatal age (PNA) of 11 weeks (range 5-21 weeks). The mean PMA at diagnosis of type 1 ROP increased with GA (35 weeks for GA of 22-24 weeks, 41 weeks for GA of 29-30 weeks), but the mean PNA at diagnosis of type 1 ROP was similar (11-13 weeks) across GA of 22-29 weeks. GA and BW dominate the association (area under the receiver operating characteristic curve=0.87, 95% CI 0.86 to 0.88).
CONCLUSIONS: Type 1 ROP developed in about 6% of premature infants over wide time windows in terms of both PMA and PNA. BW and GA are the dominant risk factors for type 1 ROP, while other prenatal factors add minimal predictive power for type 1 ROP.
Volume
105
Issue
12
First Page
1724
Last Page
1730
ISSN
1468-2079
Published In/Presented At
Yu, Y., Tomlinson, L. A., Binenbaum, G., Ying, G. S., & G-Rop Study Group (2021). Incidence, timing and risk factors of type 1 retinopathy of prematurity in a North American cohort. The British journal of ophthalmology, 105(12), 1724–1730. https://doi.org/10.1136/bjophthalmol-2020-317467
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
32980817
Department(s)
Department of Pediatrics
Document Type
Article