Daily Oxygen Supplementation and Risk of Retinopathy of Prematurity.
Publication/Presentation Date
6-1-2023
Abstract
PURPOSE: Excessive oxygen supplementation increases risk of retinopathy of prematurity (ROP). While numerous oxygen parameters could be considered when predicting ROP (saturation targets, actual saturation, fraction of inspired oxygen, etc.), complicated measures are impractical as screening criteria. We sought to develop a simple, clinically useful measure of daily oxygen supplementation during ages 0-28 days to improve prediction of ROP.
METHODS:
RESULTS: Among 8,949 studied infants, 459 (5.1%) developed type 1 ROP. DSO28 was associated with severe ROP (adjusted-OR 1.05 per day supplemental oxygen, 95%CI 1.03-1.07, p < .0001). The following criteria had 100% sensitivity for type 1 ROP and higher specificity than current guidelines: new BW/GA criteria with DSO (BW< 901 g, GA< 26 weeks, or DSO >3), 23.4% fewer infants examined; modified G-ROP criteria including DSO, 29.0% fewer infants; original G-ROP criteria, 31.8% fewer infants.
CONCLUSION: In high-level neonatal-care settings, incorporating DSO (a simple measure of oxygen supplementation) into screening criteria improves sensitivity and specificity for type 1 ROP over current BW-GA criteria, but does not perform as well as the validated G-ROP criteria.
Volume
30
Issue
3
First Page
317
Last Page
325
ISSN
1744-5086
Published In/Presented At
Estrada, M. M., Tomlinson, L. A., Yu, Y., Ying, G. S., Binenbaum, G., & G-ROP Study Group (2023). Daily Oxygen Supplementation and Risk of Retinopathy of Prematurity. Ophthalmic epidemiology, 30(3), 317–325. https://doi.org/10.1080/09286586.2022.2111687
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
36093765
Department(s)
Department of Pediatrics
Document Type
Article