Repetitive deformation and pressure activate small bowel and colonic mucosal tyrosine kinase activity in vivo.
Publication/Presentation Date
12-1-2002
Abstract
Physical forces like deformation and pressure modulate signaling and phenotype in cultured cells. However, it is more difficult to establish that such phenomena occur in vivo. We studied the effects of 0 to 10 minutes of rhythmic distension with an isotonic electrolyte and polyethylene glycol solution to 30 cm H(2)O pressure on defunctionalized small and large bowel segments in adult male Sprague Dawley rats. Mucosa was harvested at 0, 1, and 10 minutes and assayed for tyrosine kinase activity. Rhythmic distension caused a time-dependent increase in colonic mucosal tyrosine kinase activity, which was statistically significant at 10 minutes (140% +/- 41% increase, n = 5, P
Volume
51
Issue
12
First Page
1525
Last Page
1527
ISSN
0026-0495
Published In/Presented At
Basson, M. D., & Coppola, C. P. (2002). Repetitive deformation and pressure activate small bowel and colonic mucosal tyrosine kinase activity in vivo. Metabolism: clinical and experimental, 51(12), 1525–1527. https://doi.org/10.1053/meta.2002.36303
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
12489062
Department(s)
Department of Pediatrics, Department of Surgery
Document Type
Article