A Copper(II) Macrocycle Complex for Sensing Biologically Relevant Organic Anions in a Competitive Fluorescence Assay: Oxalate Sensor or Urate Sensor?
Fluorescence sensing of oxalate has garnered some attention in the past two decades as a result of this anion's prominence and impact on society. Previous work on oxalate sensors and other divalent anion sensors has led to the conclusion that the sensors are selective for the anion under investigation. However, sensor selectivity is often determined by testing against a relatively small array of "guest" molecules or analytes and studies often exclude potentially interfering compounds. For example, studies on oxalate sensors have excluded compounds such as citrate and urate, which are anions in the biological matrices where oxalate is measured (
Published In/Presented At
Hontz, D., Hensley, J., Hiryak, K., Lee, J., Luchetta, J., Torsiello, M., Venditto, M., Lucent, D., Terzaghi, W., Mencer, D., Bommareddy, A., & VanWert, A. L. (2020). A Copper(II) Macrocycle Complex for Sensing Biologically Relevant Organic Anions in a Competitive Fluorescence Assay: Oxalate Sensor or Urate Sensor?. ACS omega, 5(31), 19469–19477. https://doi.org/10.1021/acsomega.0c01655
Pharmacy and Pharmaceutical Sciences
Department of Pharmacy