New-Onset Mania With Psychotic Features in a Patient With DiGeorge Syndrome, HIV, Syphilis, and Pulmonary Hypertension.
Publication/Presentation Date
5-1-2025
Abstract
This case report describes a 34-year-old man with HIV and DiGeorge syndrome who experienced his first documented manic episode with psychotic features. On admission, he exhibited psychomotor agitation, catatonic behavior, perseveration, disorganized thoughts, hyper-religiosity, auditory hallucinations, and grandiose delusions. Initial treatment with antipsychotics was complicated by autonomic instability, limiting therapeutic options. Further evaluation revealed syphilis and pulmonary hypertension, which further complicated his hospital course. This case highlights the complexities of managing psychiatric symptoms in patients with DiGeorge syndrome and HIV, as well as the increased risk for first-break psychosis associated with a 22q11.2 deletion.
Volume
17
Issue
5
First Page
83883
Last Page
83883
ISSN
2168-8184
Published In/Presented At
Chen, G., & Pollak, M. (2025). New-Onset Mania With Psychotic Features in a Patient With DiGeorge Syndrome, HIV, Syphilis, and Pulmonary Hypertension. Cureus, 17(5), e83883. https://doi.org/10.7759/cureus.83883
Disciplines
Psychiatry
PubMedID
40497168
Department(s)
Department of Psychiatry, Fellows and Residents
Document Type
Article