Prolonged postictal encephalopathy in two patients with clozapine-induced seizures.
Two patients with prolonged postictal encephalopathy lasting 63 and 72 hours, respectively, following seizures with clozapine are reported. Clozapine alters the EEG in a majority of patients treated, with seizure frequency as high as 5-10% in doses above 600 mg/d. Prolonged postictal encephalopathy following a clozapine-induced seizure has not been previously reported but may be an important side effect of this medication. Pharmacologic and clinical issues are discussed.
Published In/Presented At
Karper, L. P., Salloway, S. P., Seibyl, J. P., & Krystal, J. H. (1992). Prolonged postictal encephalopathy in two patients with clozapine-induced seizures. The Journal of neuropsychiatry and clinical neurosciences, 4(4), 454–457. https://doi.org/10.1176/jnp.4.4.454
Department of Psychiatry