USF-LVHN SELECT
Genomic and Phenotypic Characterization of Mupirocin Resistant
Publication/Presentation Date
6-2-2025
Abstract
BACKGROUND: Colonization with
METHODS: We characterized oxacillin and mupirocin susceptibility amongst 384
RESULTS: Mupirocin resistance (MupR) was nearly exclusively present in MRSA strains (103/106 97.1% of MupR; 103/299 34.4% of MRSA). Although our hospital protocol for decolonization shifted to povidone iodine in the Post-COVID period, the overall prevalence of MupR did not change in Pre-COVID and Post-COVID samples (28.9% vs 26%). Genotype correlated with antibiotic susceptibility with low level MupR (MupLR), linked to mutations in
CONCLUSIONS: Mupirocin resistance was prevalent in our hospital MRSA strains. We also found evidence for emergence and persistence of ST3390 MRSA-MupR strains in Florida.
KEY POINTS: In a survey of clinical isolates in Florida, 34.4% of MRSA strains were mupirocin resistant. Mupirocin resistance correlated with mutations in
ISSN
2692-8205
Published In/Presented At
Virgillio, A. M., Felton, E. A., Jackson, J. K., Kennedy, S. J., Becker, D. N., Lima, A., Atrubin, K., Cella, E., Azarian, T., Silbert, S., Shaw, L. N., & Kim, K. (2025). Genomic and Phenotypic Characterization of Mupirocin Resistant Staphylococcus aureus Clinical Isolates. bioRxiv : the preprint server for biology, 2025.04.16.648996. https://doi.org/10.1101/2025.04.16.648996
Disciplines
Medical Education | Medicine and Health Sciences
PubMedID
40501773
Department(s)
USF-LVHN SELECT Program, USF-LVHN SELECT Program Students
Document Type
Article