Both Hoxc13 orthologs are functionally important for zebrafish tail fin regeneration.
Publication/Presentation Date
6-1-2007
Abstract
Hox genes are re-expressed during regeneration in many species. Given their important role in body plan development, it has been assumed, but not directly shown, that they play a functional role in regeneration. In this paper we show that morpholino-mediated knockdown of either Hoxc13a or Hoxc13b during the process of zebrafish tail fin regeneration results in a significant reduction of regenerative outgrowth. Furthermore, cellular proliferation within the blastema is directly affected in both knockdowns. Hence, similar to the demonstration of unique functions of multiple Hox genes during limb formation, both Hoxc13 orthologs have distinct functions in regeneration.
Volume
217
Issue
6
First Page
413
Last Page
420
ISSN
0949-944X
Published In/Presented At
Thummel, R., Ju, M., Sarras, M. P., Jr, & Godwin, A. R. (2007). Both Hoxc13 orthologs are functionally important for zebrafish tail fin regeneration. Development genes and evolution, 217(6), 413–420. https://doi.org/10.1007/s00427-007-0154-3
Disciplines
Medicine and Health Sciences
PubMedID
17437127
Department(s)
Department of Surgery
Document Type
Article