Fluorocarbon Enhancement of Skin Flap Survival in Rats.
Publication/Presentation Date
1-1-1987
Abstract
Fluorocarbons exhibit two unique properties: oxygen saturation in direct proportion to the percent administered and low viscosity which improves microcirculation. These properties were investigated in improving survival in random skin flaps in rats. Modified McFarlane flaps were raised in 30 Sprague-Dawley rats and divided into three equal groups. Group 1 rats served as controls, group 2 rats were hemodiluted with Ringer's lactate, and group 3 rats were hemodiluted with Fluosol-DA (20%). All groups were kept in a high (80%) oxygen environment for 48 hours. Areas of necrosis were measured using a computer system. Necrosis in control flaps averaged 14.96 percent; in flaps hemodiluted with Ringer's lactate, 10.12 percent; in flaps hemodiluted with Fluosol, 4.76 percent. These differences were statistically significant. We conclude that fluorocarbons significantly enhance flap survival in rats.
Volume
79
Issue
1
First Page
98
Last Page
101
ISSN
0032-1052
Published In/Presented At
Chowdary, R. P., Berkower, A. S., Moss, M. L., & Hugo, N. E. (1987). Fluorocarbon enhancement of skin flap survival in rats. Plastic and reconstructive surgery, 79(1), 98–101. https://doi.org/10.1097/00006534-198701000-00017
Disciplines
Other Medical Specialties | Surgery
PubMedID
3797523
LVHN link
http://search.ebscohost.com/login.aspx?direct=true&db=mnh&AN=3662349&site=ehost-live&scope=site
Department(s)
Department of Surgery, Department of Surgery Faculty
Document Type
Article