Observational study of long-term persistent elevation of neurodegeneration markers after cardiac surgery.

Publication/Presentation Date

5-9-2019

Abstract

Surgery and anesthesia induce inflammatory changes in the central nervous system, which ultimately lead to neuronal damage concomitant with an increase in the level of neurodegeneration markers. Despite some experimental data showing prolonged activation of the immune system post-surgery, no study has determined the extent of long-term elevation of neurodegeneration markers. The purpose of this study was to investigate the serum levels of tau protein, ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1), neurofilament light (NF-L), and glial fibrillary acidic protein (GFAP) after elective cardiac surgery with the implementation of cardiopulmonary bypass (CPB). The serum levels of these markers from 30 patients were compared longitudinally to the baseline (pre-surgery or t

Volume

9

Issue

1

First Page

7177

Last Page

7177

ISSN

2045-2322

Disciplines

Medicine and Health Sciences

PubMedID

31073130

Department(s)

Department of Surgery

Document Type

Article

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