Observational study of long-term persistent elevation of neurodegeneration markers after cardiac surgery.
Publication/Presentation Date
5-9-2019
Abstract
Surgery and anesthesia induce inflammatory changes in the central nervous system, which ultimately lead to neuronal damage concomitant with an increase in the level of neurodegeneration markers. Despite some experimental data showing prolonged activation of the immune system post-surgery, no study has determined the extent of long-term elevation of neurodegeneration markers. The purpose of this study was to investigate the serum levels of tau protein, ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1), neurofilament light (NF-L), and glial fibrillary acidic protein (GFAP) after elective cardiac surgery with the implementation of cardiopulmonary bypass (CPB). The serum levels of these markers from 30 patients were compared longitudinally to the baseline (pre-surgery or t
Volume
9
Issue
1
First Page
7177
Last Page
7177
ISSN
2045-2322
Published In/Presented At
DiMeglio, M., Furey, W., Hajj, J., Lindekens, J., Patel, S., Acker, M., Bavaria, J., Szeto, W. Y., Atluri, P., Haber, M., Diaz-Arrastia, R., & Laudanski, K. (2019). Observational study of long-term persistent elevation of neurodegeneration markers after cardiac surgery. Scientific reports, 9(1), 7177. https://doi.org/10.1038/s41598-019-42351-2
Disciplines
Medicine and Health Sciences
PubMedID
31073130
Department(s)
Department of Surgery
Document Type
Article