Deviation from optimal vascular caliber control at middle cerebral artery bifurcations harboring aneurysms.
Publication/Presentation Date
10-17-2014
Abstract
Cerebral aneurysms form preferentially at arterial bifurcations. The vascular optimality principle (VOP) decrees that minimal energy loss across bifurcations requires optimal caliber control between radii of parent (r₀) and daughter branches (r1 and r2): r₀(n)=r₁(n)+r₂(n), with n approximating three. VOP entails constant wall shear stress (WSS), an endothelial phenotype regulator. We sought to determine if caliber control is maintained in aneurysmal intracranial bifurcations. Three-dimensional rotational angiographic volumes of 159 middle cerebral artery (MCA) bifurcations (62 aneurysmal) were processed using 3D gradient edge-detection filtering, enabling threshold-insensitive radius measurement. Radius ratio (RR)=r₀(3)/(r₁(3)+r₂(3)) and estimated junction exponent (n) were compared between aneurysmal and non-aneurysmal bifurcations using Student t-test and Wilcoxon rank-sum analysis. The results show that non-aneurysmal bifurcations display optimal caliber control with mean RR of 1.05 and median n of 2.84. In contrast, aneurysmal bifurcations had significantly lower RR (0.76, p
Volume
47
Issue
13
First Page
3318
Last Page
3324
ISSN
1873-2380
Published In/Presented At
Baharoglu, M. I., Lauric, A., Wu, C., Hippelheuser, J., & Malek, A. M. (2014). Deviation from optimal vascular caliber control at middle cerebral artery bifurcations harboring aneurysms. Journal of biomechanics, 47(13), 3318–3324. https://doi.org/10.1016/j.jbiomech.2014.08.012
Disciplines
Medicine and Health Sciences
PubMedID
25242132
Department(s)
Department of Surgery
Document Type
Article