Laser interstitial thermal therapy in drug-resistant epilepsy.

Publication/Presentation Date

4-1-2019

Abstract

PURPOSE OF REVIEW: MRI-guided stereotactic laser interstitial thermal therapy (LiTT) has been utilized in the surgical treatment of discrete, small epileptogenic lesions. This review summarizes the current literature and addresses the clinical application of this technique.

RECENT FINDINGS: LiTT has the potential to reduce the morbidity and discomfort of epilepsy surgery. Review of data from retrospective, uncontrolled studies suggests that LiTT may offer benefit when treating drug-resistant epilepsy because of mesial temporal sclerosis, hypothalamic hamartoma, cavernous hemangioma, and small cortical dysplasias and malformations. It is now being offered as initial therapy in place of anterior temporal lobectomy in many centers, and a prospective study is underway to compare it with historical temporal lobectomy reports.

SUMMARY: LiTT appears promising and has potential for reduced morbidity and improved tolerability compared with open surgery. Studies must be done to compare efficacy and safety of LiTT with open surgery, and further investigation is needed to optimize this technique.

Volume

32

Issue

2

First Page

237

Last Page

245

ISSN

1473-6551

Disciplines

Medicine and Health Sciences

PubMedID

30694919

Department(s)

Department of Surgery

Document Type

Article

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