Stimulation better targets fast-ripple generating networks in super responders to the responsive neurostimulator system.
Publication/Presentation Date
5-1-2023
Abstract
How responsive neurostimulation (RNS) decreases seizure frequency is unclear. Stimulation may alter epileptic networks during inter-ictal epochs. Definitions of the epileptic network vary but fast ripples (FRs) may be an important substrate. We, therefore, examined whether stimulation of FR-generating networks differed in RNS super responders and intermediate responders. In 10 patients, with subsequent RNS placement, we detected FRs from stereo-electroencephalography (SEEG) contacts during pre-surgical evaluation. The normalized coordinates of the SEEG contacts were compared with those of the eight RNS contacts, and RNS-stimulated SEEG contacts were defined as those within 1.5 cm
Volume
64
Issue
5
First Page
48
Last Page
48
ISSN
1528-1167
Published In/Presented At
Weiss, S. A., Eliashiv, D., Stern, J., Rubinstein, D., Fried, I., Wu, C., Sharan, A., Engel, J., Staba, R., & Sperling, M. R. (2023). Stimulation better targets fast-ripple generating networks in super responders to the responsive neurostimulator system. Epilepsia, 64(5), e48–e55. https://doi.org/10.1111/epi.17582
Disciplines
Medicine and Health Sciences
PubMedID
36906958
Department(s)
Department of Surgery
Document Type
Article