Cerebral uric acid increases following experimental traumatic brain injury in rat.
Publication/Presentation Date
9-16-1996
Abstract
Following traumatic brain injury (TBI), cortical and thalamic areas were analyzed histologically and by high-performance liquid chromatography with electrochemical detection for uric acid at various survival times. Following TBI, cortical uric acid was elevated by ten-fold at 24 and 48 h, but not at 1 h post-TBI. Histological evidence of neurodegeneration was found not only in cortex but also in the anteroventral thalamus. These data suggest that as in stroke, uric acid measurements may be a convenient and sensitive method for measuring peroxidative status in TBI.
Volume
733
Issue
2
First Page
287
Last Page
291
ISSN
0006-8993
Published In/Presented At
Tayag, E. C., Nair, S. N., Wahhab, S., Katsetos, C. D., Lighthall, J. W., & Lehmann, J. C. (1996). Cerebral uric acid increases following experimental traumatic brain injury in rat. Brain research, 733(2), 287–291. https://doi.org/10.1016/0006-8993(96)00669-5
Disciplines
Medicine and Health Sciences
PubMedID
8891312
Department(s)
Department of Surgery
Document Type
Article