Local Control in Patients with Metastatic Renal Cell Carcinoma to the Spine: The Experience of an Institution with a Multidisciplinary Spine Oncology Program.
Publication/Presentation Date
10-1-2023
Abstract
BACKGROUND: The outcomes for patients with metastatic renal cell carcinoma (RCC) to the spine who underwent stereotactic body radiotherapy (SBRT) through a multidisciplinary spine oncology program are not well described. We sought to describe the clinical course and local control rates at 1 and 2 years for these patients.
METHODS: A retrospective analysis of a prospectively maintained database of adult oncologic patients receiving SBRT to the spine through a multidisciplinary spine oncology program at a single institution from 2010 to 2021 was performed. Patients with a pathologic diagnosis of RCC were included.
RESULTS: A total of 75 spinal sites were treated in 60 patients. Of the 60 patients, 75.0% were men, and the mean patient age was 59.2 ± 11.3 years. At 1 year after treatment, 6 of the 60 patients were lost to follow-up. Of the remaining 54 patients, 18 were censored by death and 7 treatment sites showed local recurrence, for 37 of 44 treatment sites with local control (87.8%). At 2 years, 1 additional local recurrence had developed, 15 patients were censored by death, and no additional patients had been lost to follow-up, resulting in 28 of 36 treatment sites with local control (83.2%). None of the patients who had undergone repeat SBRT had local recurrence at 1 or 2 years. For those with local recurrence, the average time from treatment to progression was 6.6 ± 6.5 months.
CONCLUSIONS: In this cohort, one of the largest reported studies of spine SBRT for metastatic RCC, local control was high at 1 and 2 years. Our findings support the role of coordinated, algorithmic treatment for these patients.
Volume
178
First Page
403
Last Page
403
ISSN
1878-8769
Published In/Presented At
Lee, J. H., Linzey, J. R., Strong, M. J., Kathawate, V. G., Goethe, P. E., Tudrick, L. R., Tripathy, A., Koduri, S., Gagnet, P., Ward, A. L., Ogunsola, O., Zaki, M. M., Joshi, R. S., Evans, J., Jackson, W. C., & Szerlip, N. J. (2023). Local Control in Patients with Metastatic Renal Cell Carcinoma to the Spine: The Experience of an Institution with a Multidisciplinary Spine Oncology Program. World neurosurgery, 178, e403–e409. https://doi.org/10.1016/j.wneu.2023.07.079
Disciplines
Medicine and Health Sciences
PubMedID
37482090
Department(s)
Department of Surgery
Document Type
Article